Hi Carol, we take this route every time to Ocracoke and some family also lives in NOVA so another reason the route is often taken.I79I6851 (right, at Cumberland towards Paw Paw)9/29 127 (left)522 (right)37 (left onto 37!)I81 (right, west or southwest direction, I guess)50 (Winchester)17 (right, towards Delaplane)I66 (east)17 (17 turns into 66 east, just follow the signs)I95It seems a bit much but it is the best way from Pittsburgh unless traveling at night and if you don’t mind a stretch where you might lose cell connectivity.There is a left turn onto 37 in Virginia to get to I81. It’s a counterintuitive direction but the fastest way to I81. Lots of traffic as you near I95 unless early morning. Do not speed in Paw Paw. You will get a ticket. Speed slows down and they really enforce it. I hope this helps.